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Name and Position

Photo of Dr Karl Gaffney

Dr Karl Gaffney


Contact Details

Main Telephone Number: 01603 289670
Fax Number: 01603 287004


Special clinical interests: ankylosing spondylitis, rheumatoid arthritis, osteoporosis

Research interests: epidemiology, imaging and therapeutics of spondyloarthropathies

Professional profile: Dr Gaffney qualified with honours in 1988 from University College Dublin. He trained in general medicine and rheumatology in Dublin and at St Bartholomew’s and The Royal London Hospitals. In 1993, he was awarded a 2 year Clinical Research Fellowship by the Arthritis Research Council UK. This work on MRI Quantification of Rheumatoid Synovitis was undertaken at the Bone & Joint Research Unit, Royal London Medical School. In 1995, Dr Gaffney was appointed as Senior Registrar at the Addenbrooke’s Hospital, Cambridge and The Norfolk & Norwich Hospital before taking up his current post.

Besides being a full time rheumatology consultant, Dr Gaffney is also the Clinical Director for Rheumatology, Clinical Research Lead, Honorary Senior Lecturer at the University of East Anglia, Chair of British Society for Rheumatology Biologics Committee for Ankylosing Spondylitis, Medical Advisor and Trustee of the National Ankylosing Spondylitis Society and President of The National Osteoporosis Society (Norwich & District Group). He was Clinical Tutor (Associate Medical Director) from 1999-2005, and Programme Director and Director of Rheumatology Training in the East of England between 2001 and 2011.


Pye SR, Marshall T, Gaffney K, Luben R, Khaw KT, Silman AJ, Symmons DP, O'Neill TW. Influence of inflammatory polyarthritis on quantitative heel ultrasound measurements. BMC Musculoskelet Disord. 2012 Jul 26;13:133

Watson P, Gaffney K. Factors influencing recruitment to rheumatology. Clin Med. 2011 Oct;11(5):509-10.

Hamilton L, Gaffney K, Andreou A, Saada J. Delayed presentation of Wegener's granulomatosis with pancreatic involvement. Int J Rheum Dis. 2011 Oct;14(4):e54-5.

Evans DM, Spencer CC, Pointon JJ, Su Z, Harvey D, Kochan G, Oppermann U, Dilthey A, Pirinen M, Stone MA, Appleton L, Moutsianas L, Leslie S, Wordsworth T, Kenna TJ, Karaderi T, Thomas GP, Ward MM, Weisman MH, Farrar C, Bradbury LA, Danoy P, Inman RD, Maksymowych W, Gladman D, Rahman P; Spondyloarthritis Research Consortium of Canada (SPARCC), Morgan A, Marzo-Ortega H, Bowness P, Gaffney K, Gaston JS, Smith M, Bruges-Armas J, Couto AR, Sorrentino R, Paladini F, Ferreira MA, Xu H, Liu Y, Jiang L, Lopez-Larrea C, Díaz-Peña R, López-Vázquez A, Zayats T, Band G, Bellenguez C, Blackburn H, Blackwell JM, Bramon E, Bumpstead SJ, Casas JP, Corvin A, Craddock N, Deloukas P, Dronov S, Duncanson A, Edkins S, Freeman C, Gillman M, Gray E, Gwilliam R, Hammond N, Hunt SE, Jankowski J, Jayakumar A, Langford C, Liddle J, Markus HS, Mathew CG, McCann OT, McCarthy MI, Palmer CN, Peltonen L, Plomin R, Potter SC, Rautanen A, Ravindrarajah R, Ricketts M, Samani N, Sawcer SJ, Strange A, Trembath RC, Viswanathan AC, Waller M, Weston P, Whittaker P, Widaa S, Wood NW, McVean G, Reveille JD, Wordsworth BP, Brown MA, Donnelly P; Australo-Anglo-American Spondyloarthritis Consortium (TASC); Wellcome Trust Case Control Consortium 2 (WTCCC2). Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility. Nat Genet. 2011 Jul 10;43(8):761-7.

Hamilton L, Gilbert A, Skerrett J, Dickinson S, Gaffney K. Services for people with ankylosing spondylitis in the UK--a survey of rheumatologists and patients. Rheumatology (Oxford). 2011 Nov;50(11):1991-8.

Keat A, Gaffney K, Marzo-Ortega H, Cornell T, MacKay K, Skerrett J, Van Rossen L, Wordsworth BP. Improving the treatment of ankylosing spondylitis in the UK. Rheumatology (Oxford). 2011 Nov;50(11):1936-9.

Pye SR, Marshall T, Gaffney K, Silman AJ, Symmons DP, O'Neill TW. Influence of arthritis and non-arthritis related factors on areal bone mineral density (BMDa) in women with longstanding inflammatory polyarthritis: a primary care based inception cohort. BMC Musculoskelet Disord. 2010 May 28;11:106.

Pradeep JD, Clunie GP, Gaffney K, Innes NJ, Brooksby A, Bradley P, Gulati A. Screening for Mycobacterium tuberculosis prior to anti-TNF therapy--an audit of impact of the British Thoracic Society guidelines on rheumatology practice in an area of low Mycobacterium tuberculosis prevalence. Rheumatology (Oxford). 2009 Feb;48(2):195.

Pradeep DJ, Keat AC, Gaffney K, Brooksby A, Leeder J, Harris C. Switching anti-TNF therapy in ankylosing spondylitis. Rheumatology (Oxford). 2008 Nov;47(11):1726-7.

Jois RN, Macgregor AJ, Gaffney K. Recognition of inflammatory back pain and ankylosing spondylitis in primary care. Rheumatology (Oxford). 2008 Sep;47(9):1364-6.

Dubey SG, Leeder J, Gaffney K. Physical therapy in anti-TNF treated patients with ankylosing spondylitis. Rheumatology (Oxford). 2008 Jul;47(7):1100-1.

Pradeep DJ, Keat A, Gaffney K. Predicting outcome in ankylosing spondylitis. Rheumatology (Oxford). 2008 Jul;47(7):942-5.

Keat AC, Gaffney K, Gilbert AK, Harris C, Leeder J. Influence of biologic therapy on return to work in people with work disability due to ankylosing spondylitis. Rheumatology (Oxford). 2008 Apr;47(4):481-3.

Lee J, Merry P, Ball R, Gaffney K. Like father, like son. Ann Rheum Dis. 2007 Dec;66(12):1686-7.

Jois RN, Gaffney K, Cane P, Nicholson AG, Wotherspoon AC. Methotrexate-associated lymphoproliferative disorder masquerading as interstitial lung disease. Histopathology. 2007 Nov;51(5):709-12. PubMed PMID: 17927594.

Thomas J, Gaffney JK. Spontaneous remission in Wegener's granulomatosis. Scand J Rheumatol. 2007 Jul-Aug;36(4):324-6.

Jois RN, Masding A, Somerville M, Gaffney K, Scott DG. Rituximab therapy in patients with resistant rheumatoid arthritis: real-life experience. Rheumatology (Oxford). 2007 Jun;46(6):980-2.

Lim AY, Ellis C, Brooksby A, Gaffney K. Patient satisfaction with rheumatology practitioner clinics: can we achieve concordance by meeting patients' information needs and encouraging participatory decision making? Ann Acad Med Singapore. 2007 Feb;36(2):110-4.

Jois RN, Gaffney K, Keat A. Anti-tumour necrosis factor therapy for ankylosing spondylitis--unresolved issues. Rheumatology (Oxford). 2007 Jun;46(6):899-901.

Lee JH, Attygalle T, Gaffney K, Scott DG. Demographics and environmental factors in a Wegener's granulomatosis cluster. Ann Rheum Dis. 2007 Feb;66(2):278-9.

Jois RN, Leeder J, Gibb A, Gaffney K, Macgregor A, Somerville M, Scott DG. Low-dose infliximab treatment for ankylosing spondylitis--clinically- and cost-effective. Rheumatology (Oxford). 2006 Dec;45(12):1566-9.

Oswald AE, Pye SR, O'Neill TW, Bunn D, Gaffney K, Marshall T, Silman AJ, Symmons DP. Prevalence and associated factors for falls in women with established inflammatory polyarthritis. J Rheumatol. 2006 Apr;33(4):690-4.

Dubey S, Gaffney K. Management of early rheumatoid arthritis. Clin Med. 2005 May-Jun;5(3):211-4.

Keat A, Barkham N, Bhalla A, Gaffney K, Marzo-Ortega H, Paul S, Rogers F, Somerville M, Sturrock R, Wordsworth P; BSR Standards, Guidelines and Audit Working group. BSR guidelines for prescribing TNF-alpha blockers in adults with ankylosing spondylitis. Report of a working party of the British Society for Rheumatology. Rheumatology (Oxford). 2005 Jul;44(7):939-47.

Lim AY, Gaffney K, Scott DG. Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years. Rheumatology (Oxford). 2005 Aug;44(8):1051-5.

Lim AY, Gaffney K, Marshall T. Juvenile onset spondylodiscitis: magnetic resonance imaging changes with infliximab. Rheumatology (Oxford). 2004 Nov;43(11):1456-8.

Jois RN, Gaffney K, Marshall T, Scott DG. Chronic periaortitis. Rheumatology (Oxford). 2004 Nov;43(11):1441-6.

Marshall AT, Gaffney JK, Marshall TJ, Williams HM. Intervertebral discitis presenting as oligoarthritis. Ann Rheum Dis. 2004 Jun;63(6):634-5.

Bawa S, Gaffney K, Marshall TJ. A fine pair of buttocks. Rheumatology (Oxford). 2004 May;43(5):666-8.

Leslie KS, Gaffney K, Ross CN, Ridley S, Barker TH, Garioch JJ. A near fatal case of the dapsone hypersensitivity syndrome in a patient with urticarial vasculitis. Clin Exp Dermatol. 2003 Sep;28(5):496-8.

Wiles NJ, Scott DG, Barrett EM, Merry P, Arie E, Gaffney K, Silman AJ, Symmons DP. Benchmarking: the five year outcome of rheumatoid arthritis assessed using a pain score, the Health Assessment Questionnaire, and the Short Form-36 (SF-36) in a community and a clinic based sample. Ann Rheum Dis. 2001 Oct;60(10):956-61.

Lane SE, Gaffney K, Ball RY, Marshall TJ. A swollen leg unmasks ongstanding SLE. Lupus. 2001;10(1):4-8.

Clark E, Gaffney K, Merry P. Ear, ear, what's going on in Norfolk? Ann Rheum Dis. 1999 Oct;58(10):660.

O'Gradaigh D, Blundell C, Marshall T, Gaffney K, Chapman P. Unusual and memorable. Periostitis and bone proliferation. Ann Rheum Dis. 1999 May;58(5):263.

Gaffney K, Scott DG. Azathioprine and cyclophosphamide in the treatment of rheumatoid arthritis. Br J Rheumatol. 1998 Aug;37(8):824-36.

Gaffney K, Cookson J, Blades S, Coumbe A, Blake D. Quantitative assessment of the rheumatoid synovial microvascular bed by gadolinium-DTPA enhanced magnetic resonance imaging. Ann Rheum Dis. 1998 Mar;57(3):152-7.

Macey MG, McCarthy DA, Gaffney K, Perry JD, Brown KA, Newland AC. CD11b positive blood lymphocytes correlate with disease activity in patients with RA. Clin Exp Rheumatol. 1998 Jan-Feb;16(1):108-9.

Jawed S, Gaffney K, Blake DR. Intra-articular pressure profile of the knee joint in a spectrum of inflammatory arthropathies. Ann Rheum Dis. 1997 Nov;56(11):686-9.

Blake DR, Stevens CR, Sahinoglu T, Ellis G, Gaffney K, Edmonds S, Benboubetra M, Harrison R, Jawed S, Kanczler J, Millar TM, Winyard PG, Zhang Z. Xanthine oxidase: four roles for the enzyme in rheumatoid pathology. Biochem Soc Trans. 1997 Aug;25(3):812-6.

Gaffney K, Jolliffe V, Merry P. Interosseous nerve entrapment syndromes complicating inflammatory arthritis. Clin Exp Rheumatol. 1997 May-Jun;15(3):339-40.

Dai L, Zhang Z, Winyard PG, Gaffney K, Jones H, Blake DR, Morris CJ. A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radic Biol Med. 1997;22(4):705-10.

Gaffney K, Merry P. Antineutrophil cytoplasmic antibody-positive polyarthritis associated with minocycline therapy. Br J Rheumatol. 1996 Dec;35(12):1327.

Marok R, Winyard PG, Coumbe A, Kus ML, Gaffney K, Blades S, Mapp PI, Morris CJ, Blake DR, Kaltschmidt C, Baeuerle PA. Activation of the transcription factor nuclear factor-kappaB in human inflamed synovial tissue. Arthritis Rheum. 1996 Apr;39(4):583-91.

Gaffney K, Cookson J, Blake D, Coumbe A, Blades S. Quantification of rheumatoid synovitis by magnetic resonance imaging. Arthritis Rheum. 1995 Nov;38(11):1610-7.

Gaffney K, Williams RB, Jolliffe VA, Blake DR. Intra-articular pressure changes in rheumatoid and normal peripheral joints. Ann Rheum Dis. 1995 Aug;54(8):670-3.

Jorizzo JL, Abernethy JL, White WL, Mangelsdorf HC, Zouboulis CC, Sarica R, Gaffney K, Mat C, Yazici H, al Ialaan A, et al. Mucocutaneous criteria for the diagnosis of Behçet's disease: an analysis of clinicopathologic data from multiple international centers. J Am Acad Dermatol. 1995 Jun;32(6):968-76.

Gaffney K, Ledingham J, Perry JD. Intra-articular triamcinolone hexacetonide in knee osteoarthritis: factors influencing the clinical response. Ann Rheum Dis. 1995 May;54(5):379-81.

Naughton DP, Knappitt J, Fairburn K, Gaffney K, Blake DR, Grootveld M. Detection and investigation of the molecular nature of low-molecular-mass copper ions in isolated rheumatoid knee-joint synovial fluid. FEBS Lett. 1995 Mar 20;361(2-3):167-72.

Gaffney K, Edmonds SE, Stevens CR, Blake DR. Pressure and vascular changes in mobile joints: implications for inflammatory joint disease. Scand J Rheumatol Suppl. 1995;101:21-6.

Edmonds SE, Ellis G, Gaffney K, Archer J, Blake DR. Hypoxia and the rheumatoid joint: immunological and therapeutic implications. Scand J Rheumatol Suppl. 1995;101:163-8.

Gaffney K, Kearns G, Moraes D, O'Dowd JF, Casey EB. Eosinophilic fasciitis: a good response with conservative treatment. Ir J Med Sci. 1993 Jul;162(7):256-7.


Member of the General Medical Council (Registration No:3622210)

Based at the Norfolk and Norwich University Hospital, Norwich and the Cromer and District Hospital, Cromer Click to show full address details for the Norfolk and Norwich University Hospital, Norwich (opens in new window) Click to show full address details for the Cromer and District Hospital, Cromer (opens in new window)

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